The AirJector•Vet uses RespiDox pharmaceutical CO2 to mix and vaporize with warm water into a therapeutic gas-mist that is enclosed around the therapy site in a sealed and safe environment. This sealed atmosphere maximizes the continuous transfer of gas into the tissue for the full twenty to twenty five minute therapy cycle.
Clinical research has shown positive effects of transcutaneous pharmaceutical carbon dioxide in the treatment of peripheral vascular disease, exercise endurance, skin grafts, wound healing, muscle disuse, tumorigenesis, bone fractures, and laminitis.
Transdermal pharmaceutical carbon dioxide dramatically increases tissue blood flow and oxygenation through a physiological process called the Bohr Effect. "Increases in tissue carbon dioxide directly activates the biologic cascade leading to angiogenesis. Angiogenesis is the natural process whereby new blood vessels are formed. New blood vessels are needed when the metabolic demand outstrips the delivery of oxygenated blood (e.g. during heavy exercise) and when tissue is stressed, or damaged, and therefore needs new blood vessels to heal and form fresh new tissue.".
Studies with appropriate experimental controls have shown many positive therapeutic responses including:
- Reduction of symptoms from peripheral vascular disease including claudication
- Increased oxygenation, blood flow, and blood vessels in ischemic limbs
- Enhanced endurance
- More rapid healing of fractures
- Suppressed metastasis of oral squamous cell carcinoma
- Induced tumor cell apoptosis and suppressed metastasis
- Improved Raynaud’s disease
- Repaired skeletal muscle
- Increased blood vessel formation in skin flaps for plastic surgery
- Stimulation of immune responses and raised endorphins
- Increased skin blood flow
Additional biological benefits of pharmaceutical carbon dioxide include:
- Increased nitric oxide thus enhancing flow dependent dilation
- Increased mitochondrial biogenesis
- Promotion of VEGF upregulation
- Neovascularization and capillary growth
- Activation of myogenesis thus accelerating muscle injury repair over fibrosis
- Suppression of the growth of metastatic squamous cells and osteosarcoma